Macaroni and Cheese Meatloaf Casserole

A comforting casserole that layers a ketchup-glazed meatloaf base with creamy macaroni and cheese — family-friendly, hearty, and easy to prepare.

Why You'll Love This Recipe
- This dinner brings together two classic favorites—meatloaf and macaroni and cheese—into one easy, crowd-pleasing dish that serves about six and reheats beautifully.
 - Ready from start to table in roughly 75 minutes, it fits weeknight schedules while still tasting like a weekend meal; active prep is only about 15 minutes.
 - Uses common pantry staples—dry elbow pasta, canned condensed soup, basic spices, store-bought crackers—which makes it an accessible, no-fuss option on busy nights.
 - Make-ahead friendly: you can assemble the meat layer the night before and bake the next day, or fully assemble and freeze for a comforting meal later.
 - Flexible for families: swap cheeses, use turkey or a beef/turkey mix for a lighter option, and adjust seasoning easily to taste.
 - Generous leftovers — it holds its flavor when reheated and is an ideal lunch the next day.
 
As a parent, I love that this dish satisfies picky eaters and adventurous adults alike. One of my favorite memories is serving it after my kids' school play; it was the warm, familiar dish that wrapped up a long day and made everyone feel at home. Over time I've tweaked the seasoning balance and glaze to hit the sweet-and-savory notes our family prefers, and now it's practically become a tradition.
Ingredients
- Tomato ketchup and BBQ sauce: Use 1/2 cup of each for a tangy-sweet glaze that keeps the meat moist. I like Heinz ketchup and a smoky Kansas City–style BBQ sauce for depth.
 - Lean ground beef: 1 pound of 90% lean beef gives me good mouthfeel without excessive grease; leaner meat reduces shrinkage and keeps the casserole tidy.
 - Crackers: About 15 Ritz-style crackers crushed finely act as a binder and add subtle buttery flavor—salted crackers replace salt in the meat layer.
 - Dry onion soup mix: 1 ounce (roughly half a standard packet) adds concentrated savory seasoning; if you prefer, swap for 1 tablespoon onion powder plus 1 teaspoon beef bouillon.
 - Egg: One large egg binds the meat without making it dense—free-range if available for richer flavor.
 - Dry macaroni: 1 1/2 cups (about 6 ounces) of small elbows or shells cooks up to a tender, saucy pasta that holds the cheese sauce well.
 - Whole milk: 1 cup keeps the cheese sauce creamy; substitute 2% for a slightly lighter result but whole milk gives the best mouthfeel.
 - Condensed cheddar cheese soup: Use half a 10.5-ounce can (roughly 5 ounces) for instant creaminess—see note below for a from-scratch cheese sauce alternative.
 - Seasonings: 1/2 teaspoon salt, 1/2 teaspoon black pepper, 1/2 tablespoon garlic powder, and 1/2 tablespoon onion powder for balanced savory flavor in the pasta layer.
 - Cheese blend: 2 cups shredded mozzarella and cheddar (about 8 ounces) divided—use a 50/50 blend for gooey melt and sharp flavor; freshly shredded cheese melts more smoothly than pre-shredded varieties.
 
Instructions
Preheat and prepare: Preheat the oven to 350°F (180°C, gas mark 4). Butter a 9-inch square baking dish so the meat layer releases easily after baking. Put a saucepan of lightly salted water on to boil for the pasta. Setting up these basic elements first saves time and keeps the workflow smooth. Crush crackers: Place 15 Ritz-style crackers into a resealable plastic bag and crush them with a rolling pin until very fine. Fine crumbs distribute through the meat without leaving large pieces that can create uneven texture. Mix the glaze: Whisk together 1/2 cup ketchup and 1/2 cup BBQ sauce in a medium bowl. Reserve half of this mixture for glazing the meat after it goes into the pan; the other half goes into the meat mixture to flavor and moisten the base. Combine meat mixture: In the mixing bowl, crumble 1 pound lean ground beef and add the crushed crackers, 1 ounce dry onion soup mix, half of the sauce mixture, and 1 beaten large egg. Gently combine with a fork—overworking can make the meat dense. Press into the prepared dish and spread the reserved glaze evenly over the top. Bake the base: Bake the meat layer in the preheated oven for 30 minutes. The partial bake firms the meat and allows juices to settle before the saucy pasta is added on top. Cook the pasta: While the meat bakes, cook 1 1/2 cups dry macaroni in the boiling salted water according to package directions until just tender. Drain thoroughly, rinse under cold water to stop cooking and prevent sticking, then drain again so the pasta is ready to fold into the cheese sauce. Make the cheese mixture: In a large bowl, whisk together 1/2 can condensed cheddar soup and 1 cup whole milk until smooth. Stir in salt, pepper, garlic powder, and onion powder. Fold in the cooked macaroni and half of the shredded cheese so the pasta is well coated. Assemble and finish baking: After the meatline has baked 30 minutes, remove it from the oven and pour the macaroni mixture over the meat base, spreading evenly. Sprinkle the remaining 1 cup of shredded cheese over top. Return to the oven and bake for 20 to 25 minutes until the top is melted and bubbling and edges show gentle browning. Rest and serve: Let the casserole sit for about 5 minutes after baking to set. This rest helps it slice cleanly and allows flavors to meld before you serve warm squares straight from the pan.
You Must Know
- This dish freezes well for up to 3 months if baked and wrapped tightly in foil; thaw overnight in the refrigerator before reheating.
 - High in protein and very filling—estimate roughly 520 calories per serving when divided into six portions, with about 30 g fat and 28 g protein per portion.
 - If you prefer lower sodium, use low-sodium ketchup and reduced-sodium onion soup mix; taste the cheese mixture before adding salt to avoid over-seasoning.
 - Leftovers reheat well in a 350°F oven covered with foil for 15–20 minutes, or in the microwave in single portions for 1–2 minutes until hot.
 
My favorite part about this casserole is how adaptable it is—feeding a crowd is simple, and the flavors seem to improve a little on the second day. Friends who tasted it at a potluck kept asking for the recipe, and it’s been a reliable recipe for rainy evenings and post-soccer-game dinners ever since.
Storage Tips
Cool the casserole to room temperature for no more than two hours before refrigerating. Store in an airtight container or cover the baking dish tightly with plastic wrap or foil. Refrigerated portions keep well for 3 to 4 days. For longer storage, freeze in an oven-safe dish wrapped well in foil for up to three months; reheat from frozen at 350°F for about 45–60 minutes until hot in the center. When reheating refrigerated portions, cover loosely with foil to prevent the top from over-browning and heat for 15–20 minutes.
Ingredient Substitutions
If you don’t have condensed cheddar soup, make a quick cheese sauce by melting 2 tablespoons butter in a saucepan, whisking in 2 tablespoons all-purpose flour and cooking for a minute. Gradually whisk in 2 cups milk and cook until thickened, then stir in 1/4 of the cheese until smooth and season to taste. For a lighter meat layer, swap half the beef for ground turkey. Gluten-free diets can use gluten-free crackers and pasta, though texture will change slightly. For a mushroom twist, substitute half a tin of condensed mushroom soup undiluted for the cheddar soup, which creates a savory, earthier topping.
Serving Suggestions
Serve warm squares with a crisp green salad dressed in a bright vinaigrette to cut through the richness, and roasted vegetables such as broccoli or Brussels sprouts. Garnish with chopped fresh parsley for color and a squeeze of lemon if you want a bright contrast. This dish pairs well with a light-bodied red wine or an ice-cold soda for family dinners. It also makes a hearty brunch option if you pair it with scrambled eggs and fruit.
Cultural Background
This layered casserole is an American comfort-food hybrid—combining the classic meatloaf, a mid-20th-century staple, with boxed-style macaroni and cheese and canned condensed soup, both pantry conveniences that became widespread in postwar kitchens. The tomato-and-BBQ glaze nods to regional American barbecue traditions while the creamy pasta topping reflects the enduring popularity of cheese-based convenience dishes. Together they form a nostalgic, practical family meal that has been adapted across households for decades.
Seasonal Adaptations
In cooler months, add a teaspoon of smoked paprika to the cheese sauce and serve with roasted root vegetables. For summer, lighten the dish by using ground turkey, swapping whole milk for 2% and adding a handful of blanched peas or chopped bell pepper to the pasta mixture. During holiday meals, turn it into a buffet item—the dish travels well and appeals to kids and adults alike.
Meal Prep Tips
Prepare the meat layer a day ahead and cover it in the baking dish; when ready, bake for 30 minutes, then top with the cooked pasta mixture and cheese and finish baking. Alternatively, assemble fully, freeze before baking, then thaw overnight and bake as directed. For individual portions, divide into small oven-safe dishes and bake for 15–20 minutes after the initial rest so each serving is hot through.
Whether you make this for a weeknight or a gathering, the combination of a sticky-sweet meat layer and creamy macaroni topping hits that comforting place we all crave. Enjoy adjusting it to your family’s tastes and making it your own.
Pro Tips
Don’t overmix the meat—combine gently to avoid a dense texture.
Use freshly shredded cheese for a smoother melt and better flavor.
Rinse pasta under cold water after draining to stop cooking and prevent clumping.
Let the casserole rest 5 minutes before slicing so it holds together.
This nourishing macaroni and cheese meatloaf casserole recipe is sure to be a staple in your kitchen. Enjoy every moist, high protein slice — it is perfect for breakfast or as a wholesome snack any time.
FAQs about Recipes
How long do leftovers keep?
Yes. Refrigerate leftovers in an airtight container for up to 4 days and reheat in the oven at 350°F for 15–20 minutes.
Can I substitute the condensed cheese soup?
You can make a simple cheese sauce from butter, flour and milk as described in the notes if you don't have condensed cheddar soup.
Tags
Macaroni and Cheese Meatloaf Casserole
This Macaroni and Cheese Meatloaf Casserole recipe makes perfectly juicy, tender, and flavorful steak every time! Serve with potatoes and a side salad for an unforgettable dinner in under 30 minutes.

Ingredients
Meat layer
Macaroni and cheese layer
Instructions
Preheat and prepare
Preheat oven to 350°F (180°C). Butter a 9-inch square baking dish and bring a saucepan of salted water to a boil for the pasta.
Crush crackers
Place 15 crackers in a resealable bag and crush finely with a rolling pin until breadcrumbs form.
Mix glaze
Whisk together 1/2 cup ketchup and 1/2 cup BBQ sauce in a medium bowl and reserve half for glazing the meat layer.
Combine meat mixture
Crumble 1 pound ground beef into the bowl, add crushed crackers, onion soup mix, half of the sauce and 1 beaten egg. Gently mix and press into prepared dish, then spread reserved glaze on top.
Bake meat layer
Bake the meat layer for 30 minutes to set the base before topping with macaroni.
Cook pasta
Cook 1 1/2 cups dry macaroni according to package directions in boiling, salted water. Drain and rinse with cold water, then drain again.
Prepare cheese mixture
Whisk 1/2 can condensed cheddar soup with 1 cup milk, season with salt, pepper, garlic powder and onion powder. Fold in cooked macaroni and half the shredded cheese.
Assemble and finish baking
Remove meat from oven after 30 minutes, pour macaroni mixture over meat and sprinkle remaining cheese on top. Bake 20–25 minutes until bubbling and cheese is melted.
Rest and serve
Let rest 5 minutes before serving to allow the layers to set for clean slices.
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Comments (1)
This recipe looks amazing! Can't wait to try it.
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